Apostle innovations feature Apostle MagTouch Nucleic Acids Isolation Automation System, Apostle MiniMax cfDNA technologies, and others.

Apostle technologies have been applied in many world-class R&D studies, clinical laboratory settings, and public health response and surveillance. To date, over 20 million samples have been successfully processed using our technologies, and the number is quickly growing.

The MagTouch 2000 instrument is an automatic extraction and purification system for nucleic acids from various types of biological samples collected in multiple transport media. It can absorb, transfer and release magnetic beads by a magnetic rod and magnetic rod sleeve to separate magnetic beads and samples. The operation is automatic, fast and simple. Compared with our earlier model 1000, the new model 2000 is easier to use, more robust, and has a smaller foot print.

• As included in: US FDA IVD EUA - Molecular Diagnostic Tests for SARS-CoV-2

The ability to isolate and analyze circulating cell free DNA (cfDNA) at very low concentrations is becoming increasingly important, particularly in non-invasive prenatal test (NIPT), early cancer detection, and infectious disease diagnosis. Highly efficient isolation of cfDNA from complexed biological medium is a crucial step for subsequent cfDNA analysis. Apostle MiniMax technology offers a best-in-class efficiency and purity compared with conventional technologies to capture and isolate the circulating cell-free genetic materials. Its superb performance has been extensively validated. Please review the examples of publications and performance data.

• As applied in: Efficient detection and post-surgical monitoring of colon cancer with a multi-marker DNA methylation liquid biopsy. Jin et al. PNAS Feb 2, 2021;118(5) e2017421118.
• Performance independently confirmed as: "(Figure 4) Most notably, the Apostle particles outperformed all others, achieving almost 2-fold higher recovery yields than the particles supplied in the X kit".SLAS Technology Available online 17 Dec 2021
• More publications

Powered by Apostle MiniMax technology, Apostle MiniMax cfDNA Blood Collection Tube (BCT) is an excellent tool for blood cfDNA preservation during blood collection, storage and transport.
This is achieved through Apostle MiniMax cfDNA BCT’s ability to:

• Prevent the release and contamination of genomic DNA from cells in blood during storage and transportation.
• Preserve existing cfDNA in blood from degradation.
• Prevent existing cfDNA in blood from cross-linking with with other biomolecules (i.e. protein).

In summary, high cfDNA quality can be preserved with Apostle MiniMax cfDNA Blood Collection Tube for downstream applications, through the prevention of cfDNA degradation, crosslingking and contamination.

• For fast extraction and purification of viral nucleic acids from various kinds of biological samples collected in multiple transport media.
• Novel and original magnetic nanoparticle technology for nucleic acids isolation.
• Various sample types: swabs, saliva, blood.
• Optimized standardized protocol for viral total NA isolation in 30 min without heating.
• Compatible with multiple high-throughput automated nucleic acid extraction platforms.

• As included in: US FDA IVD EUA - Molecular Diagnostic Tests for SARS-CoV-2.

We have built a strong global supply chain, and provide an ample and stable supply of all the reagents and consumables required for our automatic system.
Our plastic consumables come at a high quality and a guaranteed 30-50% less cost compared with other brands on market.

• High quality: Equal or better results compared with other brands.
• Lower cost: Guaranteed 30% - 50% less cost than other brands.
• Fully compatible: Standard formats fully compatible with broad brands' nucleic acids isolation automation platforms.
• Fully validated: trusted by tests in over 10 million samples.

Our plastic consumables come at a high quality and a guaranteed 30-50% less cost compared with other brands on market.

• High quality: Filtered, Sterile, Low retention. Non-Pyrogenic and free of RNase/DNase, DNA, ATP, and PCR inhibitors. Extended length to prevent cross-contamination.
• Offered at different volume capacity:10 uL, 200 uL, 1000 uL.
• Lower cost: Guaranteed 30% - 50% less cost than other brands.
• Fully compatible: Standard universal formats fully compatible with broad brands' pipettes.
• Fully validated: thoroughly tested and validated in hundreds of millions of applications.

Precise DNA sizing can boost sequencing efficiency, reduce cost, improve data quality, and even allow sequencing of low-input samples, while current pervasive DNA sizing approaches are incapable of differentiating DNA fragments under 200 bp with high resolution (<20 bp). The Apostle MiniEnrich Short Fragments Enrichment Kit is a simple, automatable, high-resolution DNA size enrichment workflow on a magnetic nano-platform to exploit this 20 bp size difference and to enrich fetal DNA fragments from maternal blood.

• As published in: High-resolution DNA size enrichment using a magnetic nano-platform and application in non-invasive prenatal testing. Zhang et al. Analyst July 2020, 145, 5733-5739 (PDF)

Next-generation purification, size selection, and long-read size selection.

The Apostle MiniEnrich Purification Beads is designed for purification and clean-up of DNA fragments from the contaminants in NGS and molecular biology workflows. It can be used on samples after DNA isolation, fragmentation, PCR amplification, cloning, library preparation, etc. With proprietary Apostle MiniEnrich technology, the kit is featured for its more efficient removal of contaminants and recovery of DNA fragments of interest than current market-leading products.

• As published in: High-resolution DNA size enrichment using a magnetic nano-platform and application in non-invasive prenatal testing. Zhang et al. Analyst July 2020, 145, 5733-5739 (PDF)